A Comprehensive Reversal of Non- Alcoholic Fatty Liver Grade- 2 (NAFLD): Clinical Insight of Case Report Sushmita Mahadev Ninganure MD Scholar, Department of Kayachikitsa, Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar, Gujarat, India http://orcid.org/0009-0002-8436-5674 Charmi S Mehta Assistant Professor, Department of Kayachikitsa, Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar, Gujarat, India DOI: https://doi.org/10.70805/ija-care.v9i4.786 Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), a hepatic manifestation of metabolic syndrome, is rising due to sedentary lifestyles and poor diet. It involves hepatic triglyceride accumulation without significant alcohol intake. Grade 2 NAFLD, marked by moderate fatty infiltration, is a key stage for timely intervention to prevent progression into steatohepatitis or cirrhosis. In Ayurveda, it correlates with Santarpanottha Yakrit Vikara, resulting from Kapha-Meda Dushti, Agnivaishamya, and Srotorodha at the Raktavaha Srotas. This case study evaluates the efficacy of Virechana and Shamana Chikitsa in lifestyle-induced Grade 2 NAFLD. A 47-year-old female teacher presented with weight gain, central obesity, fatigue, and bloating. USG showed Grade 2 fatty liver with an incidental umbilical hernia. Ayurvedic assessment revealed Agnimandya and Kapha-Meda Dushti. Management included:Deepana-Pachana to restore Agni, Virechana Karma for systemic detoxification, Internal medicines—Katuki Churna, Phalatrikadi Kwath for Lekhana and hepatostimulation. The treatment was continued for three months with regular monitoring. Follow-up USG showed complete resolution of fatty infiltration and normalized echo-texture. The patient achieved 7 kg weight loss, improved digestion, reduced bloating, and enhanced energy levels. No adverse events occurred. This case highlights the potential of Ayurvedic interventions in reversing NAFLD. The integrative approach of Virechana with rational Shamana Chikitsa provided safe, effective, and sustainable outcomes. It emphasizes Ayurveda’s role in holistic, preventive, and personalized management of lifestyle-related hepatic disorders. pdf Published 2025-12-14 Issue Vol 9 No 4 (2025): October-December 2025 Section Case Reports This work is licensed under a Creative Commons Attribution 4.0 International License.